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Irbesartan: Angiotensin II is actually a strong vasoconstrictor shaped from angiotensin I in a response catalyzed by angiotensin-changing enzyme (ACE, kininase II). Angiotensin II will be the principal pressor agent in the RAS and also stimulates aldosterone synthesis and secretion by adrenal cortex, cardiac contraction, renal resorption of sodium, activity of the sympathetic anxious process, and sleek muscle cell development.
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Irbesartan: No information are available in regard to overdosage in people. Even so, daily doses of 900 mg for eight months were being well tolerated. The probably manifestations of overdosage are anticipated to get hypotension and tachycardia; bradycardia might also arise from overdose. Irbesartan just isn't taken off by hemodialysis.To acquire up-to-day information regarding the therapy of overdosage, a fantastic source is actually a Qualified regional Poison Management Heart. Phone numbers of Qualified Poison Command Facilities are mentioned inside the Medical professionals’ Desk Reference (PDR).
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